Methanol → Methyl 2-[[3-(trifluoromethyl)phenyl]amino]benzoate

HRID 1461425Notes

Reaction equation

HRID 1461425 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:4]=[C:5]([NH:9][C:10]2[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=2[C:12]([OH:14])=[O:13])[CH:6]=[CH:7][CH:8]=1.S(=O)(=O)(O)O.[CH3:26]O>>[F:1][C:2]([F:19])([F:20])[C:3]1[CH:4]=[C:5]([NH:9][C:10]2[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=2[C:12]([O:14][CH3:26])=[O:13])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 3371Flufenamic Acid

Product 1

HCID 200813Methyl 2-[[3-(trifluoromethyl)phenyl]amino]benzoateYield 71%

Procedure

Reaction of 2-[[3-(trifluoromethyl)phenyl]amino]benzoic acid with methanol and sulfuric acid according to the procedure of Example 26 gives a 71% yield of 2-[[3-(trifluoromethyl)phenyl]amino]benzoic acid, methyl ester as a colorless oil.

Sources & evidence

ORD record
ord-ae2bac2059954eb88fa42b0c689f8620
Source dataset
uspto-grants-1991_12
Patent number
US05075330

Reaction notes

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