4-tert-Butylphenol → Rac-4-[2-(4-tert-butyl-phenoxy)-2-fluoro-acetylamino]-thiophene-3-carboxylic acid

HRID 14617

Reaction equation

HRID 14617 reaction equation
C[O:2][C:3]([C:5]1[C:9]([NH:10][C:11](=[O:15])[CH:12](Cl)[F:13])=[CH:8][S:7][CH:6]=1)=[O:4].[C:16]([C:20]1[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=1)([CH3:19])([CH3:18])[CH3:17]>>[C:16]([C:20]1[CH:21]=[CH:22][C:23]([O:26][CH:12]([F:13])[C:11]([NH:10][C:9]2[C:5]([C:3]([OH:2])=[O:4])=[CH:6][S:7][CH:8]=2)=[O:15])=[CH:24][CH:25]=1)([CH3:19])([CH3:17])[CH3:18]

Participants

3

Reactant 2

HCID 73934-tert-ButylphenolHCID 686894624-(2-Chloro-2-fluoro-acetylamino)-thiophene-3-carboxylic acid methyl ester

Product 1

HCID 16068687Rac-4-[2-(4-tert-butyl-phenoxy)-2-fluoro-acetylamino]-thiophene-3-carboxylic acid

Procedure

In analogy to Example 58, the title compound was prepared using 4-(2-chloro-2-fluoro-acetylamino)-thiophene-3-carboxylic acid methyl ester and 4-tert-butylphenol. MS (m/e): 350.3 (M−H).

Sources & evidence

ORD record
ord-d2b7ab22b54244d1aaa331dd8619542f
Source dataset
uspto-grants-2010_06
Patent number
US07732452B2

Linked notes

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