HCID 19781570, compound → HCID 19781561, compound

Reaction equation

[F:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]([CH3:12])[O:7][C:8]2=[O:9])=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:6]([OH:7])[CH3:12])=[C:10]([CH2:8][OH:9])[CH:11]=1

Participants

Reactant 2

HCID 19781570HCID 19781570, compound

HCID 21226445Aluminium lithium hydride

Product 1

HCID 19781561HCID 19781561, compound

Procedure

This compound was prepared in an analogous manner to Example X1 from 8.0 (48 mM) of 6-fluoro-3-methylphthalide and lithium aluminium hydride to yield the title compound as a yellow oil.

Sources & evidence

ORD record: ord-6f141c46ca414a24a4470f947aea81c1
Source dataset: uspto-grants-1991_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05077299

Reaction notes

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