Formamide → HCID 178508717, compound

HRID 14625

Reaction equation

HRID 14625 reaction equation
[NH2:1][C:2]1[C:6]([C:7]#[N:8])=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([O:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:11][CH:10]=2)[NH:4][N:3]=1.O.[CH:23]([NH2:25])=O>>[NH2:8][C:7]1[N:25]=[CH:23][N:1]=[C:2]2[NH:3][N:4]=[C:5]([C:9]3[CH:14]=[CH:13][C:12]([O:15][C:16]4[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=4)=[CH:11][CH:10]=3)[C:6]=12

Participants

4

Reactant 3

HCID 713FormamideHCID 962WaterHCID 223467843-amino-5-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

Product 1

HCID 178508717HCID 178508717, compound

Conditions

Temperature
180 °C

Procedure

3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole (29.5 g) is suspended in formamide (300 mL) and heated under nitrogen at 180° C. for 4 hours. The reaction mixture is cooled to 30° C. and water (300 mL) is added. The solid is collected, washed well with water, then with methanol and dried in air to give of 4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine.

Workup

  1. temperatureThe reaction mixture is cooled to 30° C.
  2. customThe solid is collected
  3. washwashed well with water
  4. dry with materialwith methanol and dried in air

Sources & evidence

ORD record
ord-46acf40008f140e4a1df8f0c57cd1dd8
Source dataset
uspto-grants-2010_06
Patent number
US07732454B2

Linked notes

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