HCID 712731, compound → 4-(2,3-Dihydro-1,4-benzodioxine-6-carbonylamino)benzoic acid

Reaction equation

[O:1]1[C:6]2[CH:7]=[CH:8][C:9]([C:11]([NH:13][C:14]3[CH:24]=[CH:23][C:17]([C:18]([O:20]CC)=[O:19])=[CH:16][CH:15]=3)=[O:12])=[CH:10][C:5]=2[O:4][CH2:3][CH2:2]1.[OH-].[K+].O.C(O)C>>[O:1]1[C:6]2[CH:7]=[CH:8][C:9]([C:11]([NH:13][C:14]3[CH:24]=[CH:23][C:17]([C:18]([OH:20])=[O:19])=[CH:16][CH:15]=3)=[O:12])=[CH:10][C:5]=2[O:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 712731HCID 712731, compound

HCID 23714421Potassium hydroxide ethanol water

Product 1

HCID 74534144-(2,3-Dihydro-1,4-benzodioxine-6-carbonylamino)benzoic acid

Procedure

Hydrolysis of this ester with potassium hydroxide/water/ethanol at 50° C. during 2 hours yielded p-(1,4-benzodioxane-6-carboxamido)benzoic acid, melting point 278°-280° C.

Sources & evidence

ORD record: ord-c73c83881ec542e0a8bd061d711465e8
Source dataset: uspto-grants-1994_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05300522

Reaction notes

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