HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-Aminomethyl-6,8-dimethoxy-isoquinoline-4-carboxylic acid methyl-(2-pyridin-2-yl-ethyl)-amide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | {6,8-Dimethoxy-4-[methyl-(2-pyridin-2-yl-ethyl)-carbamoyl]-isoquinolin-1-ylmethyl}-carbamic acid tert-butyl ester | HCID 68613832 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-Aminomethyl-6,8-dimethoxy-isoquinoline-4-carboxylic acid methyl-(2-pyridin-2-yl-ethyl)-amide hydrochloride | HCID 68614421 | 100% |
Reaction Steps
As described in example 1, 57 mg of {6,8-dimethoxy-4-[methyl-(2-pyridin-2-yl-ethyl)-carbamoyl]-isoquinolin-1-ylmethyl}-carbamic acid tert-butyl ester was treated with HCl in EtOAc to give 74 mg (>100%) of 1-aminomethyl-6,8-dimethoxy-isoquinoline-4-carboxylic acid methyl-(2-pyridin-2-yl-ethyl)-amide hydrochloride. MS: APCI (M+H) calc'd for C21H24N4O3+H 381.4; found 381.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732446B1 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-3add24d3577741faaddc465b29367de5 |
| Source note | uspto-grants-2010_06 |