3-Methyl-2-nitro-1,1'-biphenyl → 3-Methyl-[1,1'-biphenyl]-2-amine
Reaction equation
[CH3:1][C:2]1[C:3]([N+:14]([O-])=O)=[C:4]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1>C(O)C>[NH2:14][C:3]1[C:2]([CH3:1])=[CH:7][CH:6]=[CH:5][C:4]=1[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
3-Methyl-2-nitrobiphenyl (1 g) was heated at 90°-95° C. for 28 hours with hydrated sodium sulphide (4.5 g) and ethanol (25 ml) to give 2-amino-3-methyl-biphenyl (m.p. 66°-67° C.) which was recrystallised from hexane and converted into its hydrochloride salt.
Sources & evidence
- ORD record
- ord-bdd1efac89e8405f93c262c00a09324e
- Source dataset
- uspto-grants-1994_04
- Patent number
- US05302720
Reaction notes
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