Thiophosgene → 5-Fluoro-2-biphenylylisothiocyanate

HRID 1464076

Reaction equation

HRID 1464076 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[C:15](Cl)(Cl)=[S:16]>O1CCOCC1.O>[F:8][C:5]1[CH:4]=[C:3]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:2]([N:1]=[C:15]=[S:16])=[CH:7][CH:6]=1

Participants

5

Reactant 2

HCID 10040ThiophosgeneHCID 190892194-Fluoro-2-phenylaniline

Product 1

HCID 190892755-Fluoro-2-biphenylylisothiocyanate

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

Reaction of 2-amino-5-fluorobiphenyl (7.8 g) with thiophosgene (7.2 g) in a mixture of dioxan (15 ml) and water (60 ml) at ambient temperature for 2 hours yielded 5-fluoro-2-biphenylylisothiocyanate as a brown oil.

Sources & evidence

ORD record
ord-e1352bff720d49a485c8be120371db65
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Linked notes

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