Thiophosgene → 5-Methyl-2-biphenylylisothiocyanate
Reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[C:15](Cl)(Cl)=[S:16]>O1CCOCC1.O>[CH3:8][C:5]1[CH:4]=[C:3]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:2]([N:1]=[C:15]=[S:16])=[CH:7][CH:6]=1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
Reaction of 2-amino-5-methylbiphenyl (7 g) with thiophosgene (5.7 g) in a mixture of dioxan (20 ml) and water (50 ml) at 0°-5° C. for 30 minutes and at ambient temperature for 1 hour gave 5-methyl-2-biphenylyl isothiocyanate as a yellow oil.
Sources & evidence
- ORD record
- ord-64ffec76d3064595a6440cadaf774fe3
- Source dataset
- uspto-grants-1994_04
- Patent number
- US05302720
Reaction notes
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