Thiophosgene → 4'-Chloro-2-biphenylylisothiocyanate
Reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1.[C:15](Cl)(Cl)=[S:16]>O1CCOCC1.O>[Cl:14][C:11]1[CH:12]=[CH:13][C:8]([C:3]2[C:2]([N:1]=[C:15]=[S:16])=[CH:7][CH:6]=[CH:5][CH:4]=2)=[CH:9][CH:10]=1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
Reaction of 2-amino-4'-chlorobiphenyl (8.7 g) and thiophosgene (7.4 g) in a mixture of dioxane (10 ml) and water (10 ml) at 0°-5° C. for 20 minutes and then at ambient temperature for 3 hours yielded 4'-chloro-2-biphenylylisothiocyanate (m.p. 63° C.) as a yellow solid.
Sources & evidence
- ORD record
- ord-d2a30a0e0b74402387b26136dab27c7d
- Source dataset
- uspto-grants-1994_04
- Patent number
- US05302720
Reaction notes
Loading…