Potassium Hydroxide → 4'-Chloro-2-biphenylylcyanamide
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[NH:14][C:15]([NH2:17])=S)=[CH:4][CH:3]=1.[OH-].[K+].O.O.O.C([O-])(=O)C.[Pb+2].C([O-])(=O)C>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[NH:14][C:15]#[N:17])=[CH:6][CH:7]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A suspension of N-(4'-chloro-2-biphenylyl)thiourea (7.1 g) in water (60 ml) was reacted with potassium hydroxide (15.1 g) in water (60 ml). Lead acetate trihydrate (10.3 g) in water (60 ml) was added and the mixture heated at 90°-95° C. for 1 hour to give 4'-chloro-2-biphenylylcyanamide (m.p. 106°-107° C.).
Workup
- temperaturethe mixture heated at 90°-95° C. for 1 hour
Sources & evidence
- ORD record
- ord-c69afb2dcdfd40f89c8beba727729543
- Source dataset
- uspto-grants-1994_04
- Patent number
- US05302720
Reaction notes
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