Thiophosgene → 3'-Fluoro-2-biphenylylisothiocyanate
Reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([F:14])[CH:9]=1.[C:15](Cl)(Cl)=[S:16]>O1CCOCC1.O>[F:14][C:10]1[CH:9]=[C:8]([C:3]2[C:2]([N:1]=[C:15]=[S:16])=[CH:7][CH:6]=[CH:5][CH:4]=2)[CH:13]=[CH:12][CH:11]=1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
Reaction of 2-amino-3'-fluorobiphenyl (10 g) and thiophosgene (9.2 g) in a mixture of dioxane (15 ml) and water (70 ml) at ambient temperature for 1.5 hours yielded 3'-fluoro-2-biphenylylisothiocyanate as a brown oil.
Sources & evidence
- ORD record
- ord-1682830bf5104e4ab600e2ad99caf938
- Source dataset
- uspto-grants-1994_04
- Patent number
- US05302720
Reaction notes
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