3-Oxobutyronitrile → HCID 86747770, compound

HRID 1464266

Reaction equation

HRID 1464266 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH2:9])=[CH:4][N:3]=1.[C:10]([CH2:12][C:13](=O)[CH3:14])#[N:11]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][C:13]([CH3:14])=[CH:12][C:10]#[N:11])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 755793-OxobutyronitrileHCID 70209275-(Aminomethyl)-2-chloropyridine

Product 1

HCID 86747770HCID 86747770, compoundYield 85%

Procedure

1.4 g of 2-chloro-5-pyridylmethylamine and 0.8 g of 1-cyano-2-propanone were mixed and the mixture was stirred at room temperature over night. The solvent was then distilled off and the residue was purified by column chromatography on silica gel to afford 1.7 g of compound No. 528. m.p. 95°-98° C.

Workup

  1. distillationThe solvent was then distilled off
  2. customthe residue was purified by column chromatography on silica gel

Sources & evidence

ORD record
ord-0787945b338f4211b0c021907cfd5215
Source dataset
uspto-grants-1994_04
Patent number
US05304566

Linked notes

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