Ethyl 2-(4-bromophenoxy)acetate → 2-(4-Bromophenoxy)acetamide

HRID 1465435

Reaction equation

HRID 1465435 reaction equation
CO.[NH3:3].[Br:4][C:5]1[CH:17]=[CH:16][C:8]([O:9][CH2:10][C:11](OCC)=[O:12])=[CH:7][CH:6]=1>>[Br:4][C:5]1[CH:17]=[CH:16][C:8]([O:9][CH2:10][C:11]([NH2:3])=[O:12])=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 248825Ethyl 2-(4-bromophenoxy)acetateHCID 21705897Ammonia methanol

Product 1

HCID 3028642-(4-Bromophenoxy)acetamideYield 98%

Procedure

7M-Ammonia methanol solution (10 ml, 70 mmol) was added to ethyl 2-(4-bromophenoxy)acetate (1.0 g, 3.86 mmol), and the mixture was stirred at room temperature for 2.5 hrs. The reaction mixture was concentrated under reduced pressure to give 2-(4-bromophenoxy)acetamide (870 mg, yield 98%) as a white solid.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-0474a42cf25b40b6b4b1e58b784d031d
Source dataset
uspto-grants-2015_04
Patent number
US08999989B2

Linked notes

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