Acetic Anhydride → N-(1-(tert-Butyl)-3-methyl-1H-pyrazol-5-yl)acetamide

HRID 1466209Notes

Reaction equation

HRID 1466209 reaction equation
[C:1]([N:5]1[C:9]([NH2:10])=[CH:8][C:7]([CH3:11])=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[C:1]([N:5]1[C:9]([NH:10][C:12](=[O:14])[CH3:13])=[CH:8][C:7]([CH3:11])=[N:6]1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 7372001-tert-Butyl-3-methyl-1H-pyrazol-5-amine

Product 1

HCID 6621900N-(1-(tert-Butyl)-3-methyl-1H-pyrazol-5-yl)acetamide

Procedure

To 1-(tert-butyl)-3-methyl-1H-pyrazol-5-amine (110 g, 0.71 mol), acetic anhydride (73 ml, 0.71 mol) was added dropwise with stirring. The reaction mixture was stirred for 1-2 h at 20-35° C. Thereafter the reaction mixture was washed with excess of hexane and filtered to obtain the title compound as a yellow solid. MP: 118-120° C.

Workup

  1. stirringThe reaction mixture was stirred for 1-2 h at 20-35° C
  2. washThereafter the reaction mixture was washed with excess of hexane
  3. filtrationfiltered

Sources & evidence

ORD record
ord-a75fe8f3cd8a438e986c2deec58880fe
Source dataset
uspto-grants-2015_04
Patent number
US09000007B2

Reaction notes

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