Potassium Hydroxide → 1-Amino-4,4-difluorocyclohexanecarboxylic acid
Reaction equation
[F:1][C:2]1([F:14])[CH2:13][CH2:12][C:5]2([NH:9]C(=O)N[C:6]2=[O:11])[CH2:4][CH2:3]1.[OH-:15].[K+]>>[NH2:9][C:5]1([C:6]([OH:15])=[O:11])[CH2:12][CH2:13][C:2]([F:14])([F:1])[CH2:3][CH2:4]1Participants
3
Procedure
Under nitrogen gas, 4.10 g of the compound of Example 2A were suspended in 100 ml of 30% strength aqueous potassium hydroxide solution, and the mixture was stirred at reflux overnight. The mixture was concentrated to about 25% of the volume and, at 0-10° C., adjusted to pH 5.5 using concentrated aqueous hydrogen chloride solution. The solution was concentrated and dried. The residue (4.30 g) was used directly for the esterification.
Workup
- temperatureat reflux overnight
- concentrationThe mixture was concentrated to about 25% of the volume and, at 0-10° C.
- concentrationThe solution was concentrated
- customdried
Sources & evidence
- ORD record
- ord-9068a503b04945deac0afd7308480af9
- Source dataset
- uspto-grants-2015_04
- Patent number
- US09000026B2
Reaction notes
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