tert-Butyl 4-oxopiperidine-1-carboxylate → HCID 25216420, compound

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH2:11])[CH:10]=1)[NH:7][C:6]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[CH:5]2.C([N:25]1[CH2:30][CH2:29][C:28](=O)[CH2:27][CH2:26]1)(OC(C)(C)C)=O>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:28]3[CH2:29][CH2:30][NH:25][CH2:26][CH2:27]3)[CH:10]=1)[NH:7][C:6]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[CH:5]2

Participants

Reactant 2

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

HCID 68478397HCID 68478397, compound

Product 1

HCID 25216420HCID 25216420, compound

Procedure

7-Amino-5-chloro-2-phenyl-1H-indole prepared in Example 3 and 1-BOC-4-piperidinone were reacted according to the same procedure as Step B of Example 1 to give the title compound.

Sources & evidence

ORD record: ord-7fe7bd6bfceb40309221a3909c0f97f9
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09000028B2

Reaction notes

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