HCID 66847104, compound → HCID 66847277, compound
Reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:17][CH3:18])=[C:6]([C:8]2[N:9]=[C:10]([CH3:16])[S:11][C:12]=2C(O)=O)[CH:7]=1.BrC1SC([NH:34][C:35](=[O:41])[O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=C(C2C=C(Cl)C=CC=2OC)N=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:17][CH3:18])=[C:6]([C:8]2[N:9]=[C:10]([CH3:16])[S:11][C:12]=2[NH:34][C:35](=[O:41])[O:36][C:37]([CH3:40])([CH3:39])[CH3:38])[CH:7]=1Participants
3
Procedure
Using 4-(5-chloro-2-methoxyphenyl)-2-methylthiazole-5-carboxylic acid, the title compound was prepared following the synthetic procedures described for tert-butyl 2-bromo-4-(5-chloro-2-methoxyphenyl)thiazol-5-ylcarbamate to give tert-butyl 4-(5-chloro-2-methoxyphenyl)-2-methylthiazol-5-ylcarbamate. LCMS (ESI) m+H=355.3; 1H NMR (400 MHz, DMSO-d6): δ 7.40 (dd, 1H); 7.32 (d, 1H); 7.11 (d, 1H); 3.77 (s, 3H); 2.55 (s, 3H); 1.42 (s, 9H).
Workup
- customthe title compound was prepared
Sources & evidence
- ORD record
- ord-e99528a756a5423398c3b5c6ed7a1db3