4-Bromo-1-ethyl-1H-pyrazole → 3-Bromo-5-[6-chloro-1-(1-ethyl-1H-pyrazol-4-yl)-2-methyl-1H-indol-3-ylsulfanyl]-benzoic acid ethyl ester

HRID 1466844

Reaction equation

HRID 1466844 reaction equation
[CH2:1]([O:3][C:4](=[O:24])[C:5]1[CH:10]=[C:9]([S:11][C:12]2[C:20]3[C:15](=[CH:16][C:17]([Cl:21])=[CH:18][CH:19]=3)[NH:14][C:13]=2[CH3:22])[CH:8]=[C:7]([Br:23])[CH:6]=1)[CH3:2].Br[C:26]1[CH:27]=[N:28][N:29]([CH2:31][CH3:32])[CH:30]=1>>[CH2:1]([O:3][C:4](=[O:24])[C:5]1[CH:10]=[C:9]([S:11][C:12]2[C:20]3[C:15](=[CH:16][C:17]([Cl:21])=[CH:18][CH:19]=3)[N:14]([C:26]3[CH:27]=[N:28][N:29]([CH2:31][CH3:32])[CH:30]=3)[C:13]=2[CH3:22])[CH:8]=[C:7]([Br:23])[CH:6]=1)[CH3:2]

Participants

3

Reactant 2

HCID 125652014-Bromo-1-ethyl-1H-pyrazoleHCID 667650953-Bromo-5-(6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid ethyl ester

Product 1

HCID 667653353-Bromo-5-[6-chloro-1-(1-ethyl-1H-pyrazol-4-yl)-2-methyl-1H-indol-3-ylsulfanyl]-benzoic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 42, Step 4, using the following starting materials: 3-Bromo-5-(6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid ethyl ester and 4-bromo-1-ethylpyrazole.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0aab9e5301d04308975a281e6cea5e91
Source dataset
uspto-grants-2015_04
Patent number
US09000025B2

Linked notes

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