2-Amino-6-fluorobenzonitrile → HCID 66745752, compound
Reaction equation
[NH2:1][C@@H:2]([CH:5]([CH3:7])[CH3:6])[CH2:3][OH:4].[NH2:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13](F)[C:10]=1[C:11]#[N:12]>>[NH2:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13]([O:4][CH2:3][C@@H:2]([NH2:1])[CH:5]([CH3:7])[CH3:6])[C:10]=1[C:11]#[N:12]Participants
3
Procedure
Prepared as in Example 24d from (S)-2-amino-3-methylbutan-1-ol and 2-amino-6-fluoro-benzonitrile as brown solid (71%). MS 220 (MH+).
Sources & evidence
- ORD record
- ord-c5cce69e7d834265addd1342adeb2d30
- Source dataset
- uspto-grants-2015_04
- Patent number
- US09000054B2
Reaction notes
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