5-(Methylsulfonyl)-1H-indole → tert-Butyl-4-(4-(5-(methylsulfonyl)-1H-indol-1-yl)phenoxy)-piperidine-1-carboxylate

HRID 1468015

Reaction equation

HRID 1468015 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[CH:8]2)(=[O:4])=[O:3].[C:14]([O:18][C:19]([N:21]1[CH2:26][CH2:25][CH:24]([O:27][C:28]2[CH:33]=[CH:32][C:31](Br)=[CH:30][CH:29]=2)[CH2:23][CH2:22]1)=[O:20])([CH3:17])([CH3:16])[CH3:15]>>[C:14]([O:18][C:19]([N:21]1[CH2:22][CH2:23][CH:24]([O:27][C:28]2[CH:33]=[CH:32][C:31]([N:10]3[C:11]4[C:7](=[CH:6][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[CH:13][CH:12]=4)[CH:8]=[CH:9]3)=[CH:30][CH:29]=2)[CH2:25][CH2:26]1)=[O:20])([CH3:17])([CH3:15])[CH3:16]

Participants

3

Reactant 2

HCID 149732305-(Methylsulfonyl)-1H-indoleHCID 467390061-BOC-4-(4-bromophenoxy)piperidine

Product 1

HCID 67807115tert-Butyl-4-(4-(5-(methylsulfonyl)-1H-indol-1-yl)phenoxy)-piperidine-1-carboxylate

Procedure

The title compound was prepared by following the similar procedure as described in Example-1 by using 5-(methylsulfonyl)-1H-indole (intermediate-21) and tert-butyl-4-(4-bromophenoxy)piperidine-1-carboxylate (intermediate-77) (0.130 g, 24%).

Sources & evidence

ORD record
ord-6819bad5f2ff4cb986d8d9c7586376d1
Source dataset
uspto-grants-2015_04
Patent number
US09000175B2

Linked notes

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