N,N-dimethyl-1H-indole-5-carboxamide → tert-Butyl 4-((6-(5-(dimethylcarbamoyl)-1H-indol-1-yl)pyridin-3-yl) amino)piperidine-1-carboxylate

HRID 1468020Notes

Reaction equation

HRID 1468020 reaction equation
Br[C:2]1[N:7]=[CH:6][C:5]([NH:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[CH3:22][N:23]([CH3:35])[C:24]([C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)[NH:31][CH:30]=[CH:29]2)=[O:25]>>[CH3:22][N:23]([CH3:35])[C:24]([C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)[N:31]([C:2]1[N:7]=[CH:6][C:5]([NH:8][CH:9]3[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]3)=[CH:4][CH:3]=1)[CH:30]=[CH:29]2)=[O:25]

Participants

3

Reactant 2

HCID 19803690N,N-dimethyl-1H-indole-5-carboxamideHCID 86602140Tert-butyl 4-((6-bromopyridin-3-yl)amino)piperidine-1-carboxylate

Product 1

HCID 86696195tert-Butyl 4-((6-(5-(dimethylcarbamoyl)-1H-indol-1-yl)pyridin-3-yl) amino)piperidine-1-carboxylate

Procedure

The title compound was prepared by following the similar procedure as described in Example-1 by using tert-butyl 4-((6-bromopyridin-3-yl)amino)piperidine-1-carboxylate (intermediate-5) and N,N-dimethyl-1H-indole-5-carboxamide (intermediate-12).

Sources & evidence

ORD record
ord-ae15553ca3cf465ea39edb82a17e34ac
Source dataset
uspto-grants-2015_04
Patent number
US09000175B2

Reaction notes

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