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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1468043Generated: October 26, 2026

5-(Methylsulfonyl)-1H-indole → tert-Butyl-4-((6-(5-(methylsulfonyl)-1H-indol-1-yl)pyridin-2-yl)oxy)-piperidine-1-carboxylate

https://huagongshe.com/reaction/1468043

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(Methylsulfonyl)-1H-indoleHCID 14973230—
ReactantTert-butyl 4-[(6-chloropyridin-2-yl)oxy]piperidine-1-carboxylateHCID 21906058—
Producttert-Butyl-4-((6-(5-(methylsulfonyl)-1H-indol-1-yl)pyridin-2-yl)oxy)-piperidine-1-carboxylateHCID 67616036—

Reaction Steps

The title compound was prepared by following the similar procedure as described in Example-1 by using 5-(methylsulfonyl)-1H-indole (intermediate 21) and tert-butyl 4-((6-chloropyridin-2-yl)oxy)piperidine-1-carboxylate (intermediate 42) (0.19 g, 63%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09000175B2
Source datasetuspto-grants-2015_04
ORD IDord-6f284c440ce84d7e9e4fab3eee15d0a4
Source noteuspto-grants-2015_04