7-fluoro-5-methanesulfonyl-1H-indole → tert-Butyl 4-((4-(7-fluoro-5-(methylsulfonyl)-1H-indol-1-yl)thiazol-2-yl) oxy)piperidine-1-carboxylate

HRID 1468066

Reaction equation

HRID 1468066 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[CH:7]2.Br[C:16]1[N:17]=[C:18]([O:21][CH:22]2[CH2:27][CH2:26][N:25]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:24][CH2:23]2)[S:19][CH:20]=1>>[F:1][C:2]1[CH:3]=[C:4]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:5]=[C:6]2[C:10]=1[N:9]([C:16]1[N:17]=[C:18]([O:21][CH:22]3[CH2:27][CH2:26][N:25]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:24][CH2:23]3)[S:19][CH:20]=1)[CH:8]=[CH:7]2

Participants

3

Reactant 2

HCID 676161497-fluoro-5-methanesulfonyl-1H-indole2×HCID 86696185tert-Butyl 4-((4-bromothiazol-2-yl)oxy)piperidine-1-carboxylate2×

Product 1

HCID 67808085tert-Butyl 4-((4-(7-fluoro-5-(methylsulfonyl)-1H-indol-1-yl)thiazol-2-yl) oxy)piperidine-1-carboxylate

Procedure

The title compound was prepared by following the similar procedure as described in Example-1 using 7-Fluoro-5-(methylsulfonyl)-1H-indole (intermediate 22) and tert-butyl 4-((4-bromothiazol-2-yl)oxy)piperidine-1-carboxylate (intermediate 46).

Sources & evidence

ORD record
ord-ce0634d2162c4b5bb0fd605f63d8d58c
Source dataset
uspto-grants-2015_04
Patent number
US09000175B2

Linked notes

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