2,5-Dimethoxyphenylboronic acid → HCID 44219055, compound

HRID 1469375

Reaction equation

HRID 1469375 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH:7][C:8]([N:10]2[CH2:13][CH:12]([O:14][C:15]3[CH:20]=[CH:19][C:18](I)=[CH:17][N:16]=3)[CH2:11]2)=[O:9])[N:2]=1.[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][C:25]=1B(O)O>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH:7][C:8]([N:10]2[CH2:13][CH:12]([O:14][C:15]3[CH:20]=[CH:19][C:18]([C:28]4[CH:29]=[C:24]([O:23][CH3:22])[CH:25]=[CH:26][C:27]=4[O:30][CH3:31])=[CH:17][N:16]=3)[CH2:11]2)=[O:9])[N:2]=1

Participants

3

Reactant 2

HCID 27343422,5-Dimethoxyphenylboronic acidHCID 66710496US10918640, Example 14

Product 1

HCID 44219055HCID 44219055, compoundYield 83%

Procedure

This compound was prepared by the method outlined for example 5 step 6. Thus 3-(5-Iodo-pyridin-2-yloxy)-azetidine-1-carboxylic acid pyridazin-3-ylamide (100 mg, 0.25 mmol) was reacted with 2,5-Dimethoxybenzeneboronic acid (Cas. No 107099-99-0, 69 mg, 0.38 mmol) to afford title compound (84 mg, 83%) as an off-white powder. LCMS: (Method B) RT=1.19 min; m/z=408 [M+H]+.

Workup

  1. customThis compound was prepared by the method

Sources & evidence

ORD record
ord-b872c864789c47d2a2b4d2e71fe78ed8
Source dataset
uspto-grants-2015_04
Patent number
US09006269B2

Linked notes

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