Methanesulfonyl chloride → (3-{[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-methanesulfonyl-amino}-propyl)-carbamic acid tert-butyl ester

HRID 14702

Reaction equation

[C:1]([O:5][C:6](=[O:26])[NH:7][CH2:8][CH2:9][CH2:10][NH:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]2[CH:24]=[CH:23][N:22]=[C:21]([Cl:25])[N:20]=2)[CH:14]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:27][S:28](Cl)(=[O:30])=[O:29]>>[C:1]([O:5][C:6](=[O:26])[NH:7][CH2:8][CH2:9][CH2:10][N:11]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]2[CH:24]=[CH:23][N:22]=[C:21]([Cl:25])[N:20]=2)[CH:14]=1)[S:28]([CH3:27])(=[O:30])=[O:29])([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 86603243{3-[3-(2-Chloro-pyrimidin-4-yl)-benzylamino]-propyl}-carbamic acid tert-butyl ester

Product 1

HCID 86603242(3-{[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-methanesulfonyl-amino}-propyl)-carbamic acid tert-butyl ester

Procedure

Intermediate 2 from above was treated with methanesulfonyl chloride following procedure D. LC-MS showed the product had the expected M+H+ of 456.

Sources & evidence

ORD record: ord-fcc1b74afd024b68a9b2feaa93b4ebcf
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07732444B2

Linked notes

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