2-(Benzyloxy)-6-butylpyridine → 6-Butylpyridin-2-ol

HRID 1471242

Reaction equation

HRID 1471242 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH2:16][CH2:17][CH3:18])[N:10]=1)C1C=CC=CC=1.[H][H]>[Pd].C(O)C>[CH2:15]([C:11]1[N:10]=[C:9]([OH:8])[CH:14]=[CH:13][CH:12]=1)[CH2:16][CH2:17][CH3:18]

Participants

5

Reactant 2

HCID 666264812-(Benzyloxy)-6-butylpyridineHCID 178418361HCID 178418361, compound

Product 1

HCID 233521006-Butylpyridin-2-ol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a pressure reaction bottle were added 1.6 g 2-(benzyloxy)-6-butylpyridine, 0.2 g 5% palladium on carbon and 50 ml ethanol. The mixture was hydrogenated at 22 C and 40 psi hydrogen for 16 hours. Following filtration through celite and solvent removal, an oil was obtained that crystallized on standing to give 0.9 g.

Workup

  1. customTo a pressure reaction bottle
  2. filtrationfiltration through celite and
  3. customsolvent removal
  4. customan oil was obtained
  5. customthat crystallized
  6. customto give 0.9 g

Sources & evidence

ORD record
ord-697c21211a3e4662a4f9c2bf6cbc246a
Source dataset
uspto-grants-2015_04
Patent number
US09011734B2

Linked notes

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