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Methanol → HCID 178446054, compound

HRID 1471300
Notes
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Reaction equation

HRID 1471300 reaction equation
[CH3:1][N+:2]1([CH3:26])[C@@H:7]2[C@@H:8]3[O:10][C@@H:9]3[C@H:3]1[CH2:4][C@@H:5]([O:11][C:12]([C:14]([OH:25])([C:20]1[S:24][CH:23]=[CH:22][CH:21]=1)[C:15]1[S:19][CH:18]=[CH:17][CH:16]=1)=[O:13])[CH2:6]2.O.[Br-:28].[CH2:29]([OH:51])[C@H:30]1[O:35][C@H:34]([O:36][C@H:37]2[O:42][C@H:41]([CH2:43][OH:44])[C@@H:40]([OH:45])[C@H:39]([OH:46])[C@H:38]2[OH:47])[C@H:33]([OH:48])[C@@H:32]([OH:49])[C@@H:31]1[OH:50].[NH2:52][C@H:53]([C:58]([OH:60])=[O:59])[CH2:54][CH:55]([CH3:57])[CH3:56].CO>O>[CH3:1][N+:2]1([CH3:26])[C@@H:3]2[C@@H:9]3[O:10][C@@H:8]3[C@H:7]1[CH2:6][C@@H:5]([O:11][C:12]([C:14]([OH:25])([C:15]1[S:19][CH:18]=[CH:17][CH:16]=1)[C:20]1[S:24][CH:23]=[CH:22][CH:21]=1)=[O:13])[CH2:4]2.[OH2:35].[Br-:28].[CH2:43]([OH:44])[C@H:41]1[O:42][C@H:37]([O:36][C@H:34]2[O:35][C@H:30]([CH2:29][OH:51])[C@@H:31]([OH:50])[C@H:32]([OH:49])[C@H:33]2[OH:48])[C@H:38]([OH:47])[C@@H:39]([OH:46])[C@@H:40]1[OH:45].[NH2:52][C@H:53]([C:58]([OH:60])=[O:59])[CH2:54][CH:55]([CH3:57])[CH3:56]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 887MethanolHCID 6106L-LeucineHCID 7427TrehaloseHCID 178480554HCID 178480554, compound

Product 1

HCID 178446054HCID 178446054, compound

Reagents, catalysts & solvents 1

HCID 962
Water
Solvent

Procedure

Tiotropium bromide (1.4 g), trehalose dehydrate (0.3 g) and L-leucine (0.3 g) were dissolved into methanol (60 ml). The solution was shaken. Water (60 ml) was added and shaken until dissolution occurred. The resultant solution was spray dried according to the parameters outlined below.

Workup

  1. stirringshaken until dissolution
  2. customdried

Sources & evidence

ORD record
ord-326851c600ac40fa98125d7077247570
Source dataset
uspto-grants-2015_04
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US09011923B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes