2-(Benzyloxy)-5-(methoxymethoxy)pyridine → HCID 178498305, compound
Reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][O:17][CH3:18])=[CH:11][N:10]=1)C1C=CC=CC=1>CCO.[Pd]>[CH3:18][O:17][CH2:16][O:15][C:12]1[CH:13]=[CH:14][C:9]([OH:8])=[N:10][CH:11]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
To 2-(benzyloxy)-5-(methoxymethoxy)pyridine (1.8 g, 8.71 mol) in EtOH was added Pd/C (1.0 g). The mixture was charged with H2 (15 psi), stirred at rt for 45 min, filtered, and concentrated to give 5-(methoxymethoxy)pyridin-2-ol (1.35 g, quantitative yield) as a pale yellow solid. LRMS (M+H+) m/z 156.1
Workup
- additionThe mixture was charged with H2 (15 psi)
- filtrationfiltered
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-cc7ab61bd8ca4d61808166c7062ba31d
- Source dataset
- uspto-grants-2015_04
- Patent number
- US09012450B2
Reaction notes
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