Acetyl chloride → Benzyl (acetyloxy)carbamate

HRID 1475972

Reaction equation

HRID 1475972 reaction equation
[CH2:1]([O:8][C:9]([NH:11][OH:12])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:13](Cl)(=[O:15])[CH3:14]>>[C:13]([O:12][NH:11][C:9]([O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:10])(=[O:15])[CH3:14]

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 18907Benzyl hydroxycarbamate

Product 1

HCID 10954788Benzyl (acetyloxy)carbamate

Procedure

[(Benzyloxy)carbonyl]amino acetate is prepared from N-(benzyloxycarbonyl) hydroxylamine and acetyl chloride according to Scheme 1. (1.24 g, 33%), 1H NMR (500 MHz, CHLOROFORM-d) δ ppm 8.18 (1H, br. s.), 7.32-7.45 (5H, m), 5.22 (2H, s), 2.22 (3H, s).

Sources & evidence

ORD record
ord-bc0f4b07f2cd4850ba4f8b1020c2d585
Source dataset
uspto-grants-2015_04
Patent number
US09018411B2

Linked notes

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