Putrescine → Pentaerythritol

HRID 1477080

Reaction equation

HRID 1477080 reaction equation
[CH2:1]([NH2:6])[CH2:2][CH2:3][CH2:4][NH2:5].[C:7]([O:11][CH2:12][C:13]([CH2:26][O:27][C:28](=[O:31])[CH:29]=[CH2:30])([CH2:20][O:21][C:22](=[O:25])[CH:23]=[CH2:24])[CH2:14][O:15][C:16](=[O:19])[CH:17]=[CH2:18])(=[O:10])[CH:8]=[CH2:9]>CO>[OH:11][CH2:12][C:13]([CH2:26][OH:27])([CH2:20][OH:21])[CH2:14][OH:15].[C:22]([O:21][CH2:20][C:13]([CH2:26][O:27][C:28](=[O:31])[CH:29]=[CH2:30])([CH2:14][O:15][C:16](=[O:19])[CH:17]=[CH2:18])[CH2:12][O:11][C:7](=[O:10])[CH:8]=[CH2:9])(=[O:25])[CH:23]=[CH2:24].[CH2:1]([NH2:6])[CH2:2][CH2:3][CH2:4][NH2:5]

Participants

5

Reactant 2

HCID 1045PutrescineHCID 62556Pentaerythritol tetraacrylate

Product 2

HCID 8285PentaerythritolHCID 131736477Peta bda

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
10 °C

Procedure

70.40 g of 1,4-Butanediamine (BDA) (0.80 mol) was added into a round-bottom flask with a stirring, a reflux condenser and a thermometer, and cooled to 10° C. below under nitrogen. 88.00 g of methanol solution of pentaerythritol tetraacrylate (PETA) (40%, 0.1 mol) was added to the round-bottom flask, and the mixture is allowed to react at 25° C. for 24 hours. The result solution is subjected to vacuum distillation to remove excess 1,4-Butanediamine (BDA) and methanol at 90° C. for 5 hours, to yield 70.41 g of light-amber viscous material, i.e., intermediate pentaerythritol core, amino terminated dendrimer (PETA-BDA-12NH for abbreviation).

Workup

  1. customto react at 25° C. for 24 hours
  2. distillationThe result solution is subjected to vacuum distillation
  3. customto remove excess 1,4-Butanediamine (BDA) and methanol at 90° C. for 5 hours

Sources & evidence

ORD record
ord-fd81b6140b054778bd4fc5235f39b298
Source dataset
uspto-grants-2016_08
Patent number
US09403707B2

Linked notes

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