Ethylamine → [3-(2-Chloro-pyrimidin-4-yl)-benzyl]-ethyl-amine

HRID 14775

Reaction equation

[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=2)[CH:11]=O)[CH:5]=[CH:4][N:3]=1.[CH2:16]([NH2:18])[CH3:17]>>[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=2)[CH2:11][NH:18][CH2:16][CH3:17])[CH:5]=[CH:4][N:3]=1

Participants

Reactant 2

HCID 6341Ethylamine

HCID 249019653-(2-Chloro-pyrimidin-4-yl)-benzaldehyde

Product 1

HCID 86603259[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-ethyl-amine

Procedure

Intermediate 1 was coupled with ethylamine following procedure B. LC-MS showed the product had the expected M+H+ of 248.

Sources & evidence

ORD record: ord-1215636967b7414eb8c1f3c627a000b5
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07732444B2

Linked notes

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