Ethyl trifluoroacetate → N-(4-Hydroxybutyl)trifluoroacetamide
Reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][OH:6].C([O:9][C:10](=O)[C:11]([F:14])([F:13])[F:12])C>C(O)C>[F:12][C:11]([F:14])([F:13])[C:10]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][OH:6])=[O:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution (100 ml) of 4-aminobutanol (2.50 g, 28.05 mmol) and trifluoroacetic acid ethyl ester (19.92 g, 140.26 mmol) in ethanol was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure to give 4-trifluoroacetamidobutanol (11) (5.44 g, q.) as a colorless syrup.
Workup
- concentrationThe reaction mixture was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-379d547febd8476ca601119fa0fcb783
- Source dataset
- uspto-grants-2016_08
- Patent number
- US09404108B2
Reaction notes
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