Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 148Generated: October 23, 2026

tert-Butyl carbamate → 2-(Tert-butoxycarbonylamino)-6-chloroisonicotinic acid

https://huagongshe.com/en/reaction/148

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl carbamateHCID 77922—
Reactant2,6-Dichloroisonicotinic acidHCID 94830—
ReagentPotassium Phosphate, TribasicHCID 62657—
Catalyst1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)HCID 636044—
CatalystBis(dibenzylideneacetone)palladiumHCID 9811564—
Solvent1,4-DioxaneHCID 31275—
Product2-(Tert-butoxycarbonylamino)-6-chloroisonicotinic acidHCID 722120520%

Reaction Conditions

Temperature100 °C

Reaction Steps

Reagents were mixed in a 25 mL round bottom flask and flushed well with nitrogen - heated at 100 °C for 16 h. The mixture looked dark black. Could not detect any starting material or product! It was discarded.

Provenance & Evidence

Source dataset750 AstraZeneca ELN dataset
ORD IDord-7c9ead47a3324fac997f2b8af6afca02
Source note750 AstraZeneca ELN dataset