2-Amino-2-methylpropionitrile → 5-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (cyano-dimethyl-methyl)-amide

HRID 1480045

Reaction equation

HRID 1480045 reaction equation
[Cl:1][C:2]1[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[NH2:16][C:17]([CH3:21])([CH3:20])[C:18]#[N:19]>>[C:18]([C:17]([NH:16][C:8]([C:5]1[CH:4]=[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)[C:2]([Cl:1])=[CH:7][N:6]=1)=[O:10])([CH3:21])[CH3:20])#[N:19]

Participants

3

Reactant 2

HCID 880222-Amino-2-methylpropionitrileHCID 902036385-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 762827185-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (cyano-dimethyl-methyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 5-chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid and 2-amino-2-methyl-propanenitrile (CAN 19355-69-2 as starting materials and isolated (50 mg, 78%) as colorless oil; LC-MS (UV peak area, m/z) 93.8%, 294.1001 (MH+).

Workup

  1. customisolated (50 mg, 78%) as colorless oil

Sources & evidence

ORD record
ord-116c0f1a1d25480890d20d308903682a
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Linked notes

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