2-Amino-3-methanesulfonyl-2-methyl-propionitrile → N-(1-cyano-1-methyl-2-methylsulfonyl-ethyl)-5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide

HRID 1480208Notes

Reaction equation

HRID 1480208 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[NH2:19][C:20]([CH3:28])([CH2:23][S:24]([CH3:27])(=[O:26])=[O:25])[C:21]#[N:22]>>[C:21]([C:20]([NH:19][C:10]([C:7]1[CH:6]=[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[C:4]([CH:1]2[CH2:2][CH2:3]2)=[CH:9][N:8]=1)=[O:12])([CH3:28])[CH2:23][S:24]([CH3:27])(=[O:26])=[O:25])#[N:22]

Participants

3

Reactant 2

HCID 902033722-Amino-3-methanesulfonyl-2-methyl-propionitrileHCID 902036745-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid

Product 1

HCID 90204420N-(1-cyano-1-methyl-2-methylsulfonyl-ethyl)-5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide

Procedure

The title compound was synthesized in analogy to Example 112e, using 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 48c) and 2-Amino-3-methanesulfonyl-2-methyl-propionitrile (example 80a) as starting materials and isolated (1.22 g, 98%); MS (ESI, m/z): 406.6 (M+H+).

Workup

  1. customisolated (1.22 g, 98%)

Sources & evidence

ORD record
ord-3915d0df03c24e80961daa3e5bf360bd
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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