4-amino-3-(trifluoromethoxy)benzoic Acid → 4-amino-N-(1-methylpiperidin-4-yl)-3-(trifluoromethoxy)benzamide

HRID 1480798

Reaction equation

HRID 1480798 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][C:3]=1[O:11][C:12]([F:15])([F:14])[F:13].[NH2:16][CH:17]1[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]1>>[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:16][CH:17]2[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]2)=[O:8])=[CH:4][C:3]=1[O:11][C:12]([F:15])([F:14])[F:13]

Participants

3

Reactant 2

HCID 27359514-amino-3-(trifluoromethoxy)benzoic AcidHCID 27375314-Amino-1-methylpiperidine

Product 1

HCID 580151524-amino-N-(1-methylpiperidin-4-yl)-3-(trifluoromethoxy)benzamide

Procedure

The title compound was prepared according to the method described for Preparation 25 using 4-amino-3-(trifluoromethoxy)benzoic acid and 4-amino-1-methylpiperidine.

Sources & evidence

ORD record
ord-d70550fa075f4fa090491a36b1aa8c06
Source dataset
uspto-grants-2016_08
Patent number
US09409907B2

Linked notes

Loading…