Acetic Anhydride → HCID 67958188, compound

HRID 1484657

Reaction equation

HRID 1484657 reaction equation
[Br:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[CH:4][C:3]=1[OH:9].[C:10](OC(=O)C)(=[O:12])[CH3:11]>ClCCl>[C:10]([O:9][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([OH:8])[C:2]=1[Br:1])(=[O:12])[CH3:11]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 6048102-Bromoresorcinol

Product 1

HCID 67958188HCID 67958188, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 2-bromo-1,3-benzenediol (3.028 g, 16.02 mmol) in dichloromethane (70 ml), TEA (3.35 ml, 24.03 mmol) and acetic anhydride (1.512 ml, 16.02 mmol) were added under stirring. The reaction mixture was stirred at room temperature overnight. The reaction was quenched with a saturated solution of ammonium chloride (100 ml), and extracted with ethyl acetate (3 times 70 ml). The combined organic layers were dried over sodium sulphate, filtered and evaporated to afford the title compound as a black oil which was used directly used in the next step. (3.028 g)

Workup

  1. stirringThe reaction mixture was stirred at room temperature overnight
  2. customThe reaction was quenched with a saturated solution of ammonium chloride (100 ml)
  3. extractionextracted with ethyl acetate (3 times 70 ml)
  4. dry with materialThe combined organic layers were dried over sodium sulphate
  5. filtrationfiltered
  6. customevaporated

Sources & evidence

ORD record
ord-af92637e61324878b676a9c740262c00
Source dataset
uspto-grants-2016_08
Patent number
US09422272B2

Linked notes

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