Acetate → 4-(2-Chloropyridin-3-yl)morpholine

Reaction equation

[C:9](=[O:10])([O-:11])[O-:12].[CH2:15]1[CH2:16][O:17][CH2:18][CH2:19][NH:20]1.[CH3:30][c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1.[Cl:1][c:2]1[n:3][cH:4][cH:5][cH:6][c:7]1[I:8].[Cs+:13].[Cs+:14].[O-:22][C:23]([CH3:24])=[O:25].[O-:26][C:27]([CH3:28])=[O:29].[Pd+2:21]>>[Cl:1][c:2]1[n:3][cH:4][cH:5][cH:6][c:7]1[N:20]1[CH2:15][CH2:16][O:17][CH2:18][CH2:19]1

Participants

Reactant 7

HCID 175Acetate2×

HCID 1140Toluene

HCID 8083Morpholine

HCID 19660Carbonate Ion

HCID 104967Cesium cation2×

HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

HCID 27357432-Chloro-3-iodopyridine

Product 1

HCID 529403224-(2-Chloropyridin-3-yl)morpholine

Sources & evidence

ORD record: ord-f65a830665434278860d29e3446f261c
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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