3-(BOC-Amino)benzaldehyde → 1-(3-Amino-benzyl)-piperidine-4-carboxylic acid cyclopentylamide

HRID 1486693Notes

Reaction equation

HRID 1486693 reaction equation
C(O[C:4]([CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([NH:19]C(OC(C)(C)C)=O)[CH:14]=2)[CH2:8][CH2:7]1)=[O:5])C.C(OC(=O)[NH:33][C:34]1[CH:39]=[CH:38][CH:37]=[C:36](C=O)C=1)(C)(C)C.C1(NC(C2CCNCC2)=O)CCCC1>>[CH:34]1([NH:33][C:4]([CH:6]2[CH2:7][CH2:8][N:9]([CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([NH2:19])[CH:14]=3)[CH2:10][CH2:11]2)=[O:5])[CH2:39][CH2:38][CH2:37][CH2:36]1

Participants

4

Reactant 3

HCID 167407363-(BOC-Amino)benzaldehydeHCID 17604582N-cyclopentylpiperidine-4-carboxamideHCID 867065211-(3-tert-Butoxycarbonylamino-benzyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 1317367961-(3-Amino-benzyl)-piperidine-4-carboxylic acid cyclopentylamide

Procedure

The title compound is prepared according to the reactions 1.001a and 1.001d described above using (3-formyl-phenyl)-carbamic acid tert-butyl ester and piperidine-4-carboxylic acid cyclopentylamide: LC-MS A: tR=0.45 min; [M+H]+=302.40.

Sources & evidence

ORD record
ord-0d7f425f0d7a45618abb5bb986e34e2d
Source dataset
uspto-grants-2016_08
Patent number
US09428456B2

Reaction notes

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