N-tert-butylpiperidine-4-carboxamide → 1-(3-Amino-benzyl)-piperidine-4-carboxylic acid tert-butylamide

HRID 1486694Notes

Reaction equation

HRID 1486694 reaction equation
C(O[C:4]([CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([NH:19]C(OC(C)(C)C)=O)[CH:14]=2)[CH2:8][CH2:7]1)=[O:5])C.C(OC(=O)NC1C=CC=C(C=O)C=1)(C)(C)C.[C:43]([NH:47]C(C1CCNCC1)=O)([CH3:46])([CH3:45])[CH3:44]>>[C:43]([NH:47][C:4]([CH:6]1[CH2:7][CH2:8][N:9]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([NH2:19])[CH:14]=2)[CH2:10][CH2:11]1)=[O:5])([CH3:46])([CH3:45])[CH3:44]

Participants

4

Reactant 3

HCID 7175833N-tert-butylpiperidine-4-carboxamideHCID 167407363-(BOC-Amino)benzaldehydeHCID 867065211-(3-tert-Butoxycarbonylamino-benzyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 867065251-(3-Amino-benzyl)-piperidine-4-carboxylic acid tert-butylamide

Procedure

The title compound is prepared according to the reaction 1.001a and 1.001d described above using (3-formyl-phenyl)-carbamic acid tert-butyl ester and piperidine-4-carboxylic acid tert-butylamide: LC-MS A: tR=0.44 min; [M+H]+=289.92.

Sources & evidence

ORD record
ord-abad6eb77aee42579f2eb6cae1a05f6d
Source dataset
uspto-grants-2016_08
Patent number
US09428456B2

Reaction notes

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