3-Formyl-4-methylbenzoic acid → 5-Formyl-2,4-dimethylbenzoic acid

Reaction equation

[CH:1]([C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[CH3:12])[C:6]([OH:8])=[O:7])=[O:2].I[C:14]1C(C)=CC(C)=C(C=1)C(O)=O>>[CH:1]([C:3]1[C:11]([CH3:12])=[CH:10][C:9]([CH3:14])=[C:5]([CH:4]=1)[C:6]([OH:8])=[O:7])=[O:2]

Participants

Reactant 2

HCID 190191913-Formyl-4-methylbenzoic acid

HCID 230918755-Iodo-2,4-dimethylbenzoic acid2×

Product 1

HCID 717431195-Formyl-2,4-dimethylbenzoic acid

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 4.1, except 5-iodo-2,4-dimethylbenzoic acid (compound 1.3) was used in place of 3-bromo-4-methylbenzoic acid.

Sources & evidence

ORD record: ord-ca8a3171fc7b4cdc9d04a7e906d98208
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09428502B2

Reaction notes

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