Azetidine → 6-(Azetidin-1-yl)pyridine-3,4-diamine

Reaction equation

[N:1]1([C:7]2[CH:12]=[C:11]([NH2:13])[C:10]([N+:14]([O-])=O)=[CH:9][N:8]=2)[CH2:6][CH2:5]OC[CH2:2]1.N1CCC1>>[N:1]1([C:7]2[N:8]=[CH:9][C:10]([NH2:14])=[C:11]([NH2:13])[CH:12]=2)[CH2:6][CH2:5][CH2:2]1

Participants

Reactant 2

HCID 10422Azetidine

HCID 900216182-(Morpholin-4-yl)-5-nitropyridin-4-amine

Product 1

HCID 900217496-(Azetidin-1-yl)pyridine-3,4-diamine

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 151.1 and 151.2, except azetidine was used in place of morpholine.

Sources & evidence

ORD record: ord-847fb57143484f2f97bab58b4da218d9
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09428502B2

Reaction notes

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