8-Bromo-2,2,4,4-tetramethyl-6-chromanoic acid → 8-Bromo-4,4-dimethyl-6-chromanoic Acid

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([C:16]([OH:18])=[O:17])[CH:5]=[C:6]2[C:11]=1[O:10][C:9](C)(C)[CH2:8][C:7]2([CH3:15])[CH3:14].CC1(C)C2C(=CC=CC=2)OC(C(O)=O)C1>>[Br:1][C:2]1[CH:3]=[C:4]([C:16]([OH:18])=[O:17])[CH:5]=[C:6]2[C:11]=1[O:10][CH2:9][CH2:8][C:7]2([CH3:14])[CH3:15]

Participants

Reactant 2

HCID 158405358-Bromo-2,2,4,4-tetramethyl-6-chromanoic acid2×

HCID 230017694,4-Dimethylchromanoic acid

Product 1

HCID 158405348-Bromo-4,4-dimethyl-6-chromanoic Acid

Procedure

Using the same procedure as for the synthesis of 8-bromo-2,2,4,4-tetramethylchromanoic acid (Compound P) but using 4,4-dimethylchromanoic acid (100 mg, 0.49 mmol), the title compound was obtained as a white solid.

Sources & evidence

ORD record: ord-56833efb43e441f3ac97ea296a98f027
Source dataset: uspto-grants-1997_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05675024

Reaction notes

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