Methyl alpha-cyclohexyl-alpha-hydroxybenzeneacetate → 4-[Ethyl-[(4-methoxyphenyl)methyl]amino]but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate

HRID 1489223

Reaction equation

HRID 1489223 reaction equation
[CH:1]1([C:7]([OH:18])([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]([O:10][CH3:11])=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:19]([N:21]([CH2:27][C:28]1[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][CH:29]=1)[CH2:22][C:23]#[C:24]CO)[CH3:20].C[O-].[Na+]>C1(C)C=CC=CC=1>[CH:12]1([C:7]([OH:18])([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:8]([O:10][CH2:11][C:24]#[C:23][CH2:22][N:21]([CH2:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][CH:29]=2)[CH2:19][CH3:20])=[O:9])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]1

Participants

5

Reactant 3

HCID 112035Methyl alpha-cyclohexyl-alpha-hydroxybenzeneacetateHCID 42481904-[Ethyl-[(4-methoxyphenyl)methyl]amino]but-2-yn-1-olHCID 10942334Sodium Methoxide

Product 1

HCID 50442254-[Ethyl-[(4-methoxyphenyl)methyl]amino]but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

reacting methyl α-cyclohexyl-α-hydroxybenzeneacetate with said 4-[N-ethyl-(4-methoxyphenyl)methylamino]-2-butyn-1-ol in the presence of sodium methoxide in toluene to produce 4-[N-ethyl-(4-methoxyphenyl)methylamino]-2-butynyl α-cyclohexyl-α-hydroxybenzeneacetate; and

Sources & evidence

ORD record
ord-8c1e1b241027403aa4a942adb087d603
Source dataset
uspto-grants-1997_10
Patent number
US05677346

Linked notes

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