Thionyl Chloride → HCID 10786113, compound
Reaction equation
[F:1][C:2]([F:25])([CH:22]([F:24])[F:23])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:15](=[O:16])[N:14]([C@H:17]([CH3:21])[C:18](O)=[O:19])[N:13]=[CH:12]2)=[CH:7][CH:6]=1.S(Cl)([Cl:28])=O>>[F:1][C:2]([F:25])([CH:22]([F:24])[F:23])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:15](=[O:16])[N:14]([C@H:17]([CH3:21])[C:18]([Cl:28])=[O:19])[N:13]=[CH:12]2)=[CH:7][CH:6]=1Participants
3
Conditions
- Temperature
- 80 °C
Procedure
To 2.0 g of (2R)-2-[4-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]propanoic acid was added 20 ml of thionyl chloride and the mixture was stirred at 80° C. for 40 minutes. The reaction solution was concentrated under reduced pressure to give 2.1 g of (2R)-2-[4-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-4,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]propanoyl chloride as a pale yellow oil. This product was used for the next step without purification.
Workup
- concentrationThe reaction solution was concentrated under reduced pressure