Methyl 3a-amino-3,3a-dihydro-1H-isoindole-2(7aH)-carboxylate → HCID 22902199, compound
Reaction equation
[NH2:1][C:2]12[CH2:10][N:9](C(OC)=O)[CH2:8][CH:7]1[CH:6]=[CH:5][CH:4]=[CH:3]2>O>[CH2:8]1[CH:7]2[C:2]([NH2:1])([CH:3]=[CH:4][CH:5]=[CH:6]2)[CH2:10][NH:9]1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
Analogously to Step F, 1.4 g (7.2 mmol) of methyl 1-amino-8-azabicyclo[4.3.0]nona-2,4-diene-8-carboxylate are hydrolysed using 4 g of Ba(OH)2.8H2O in 20 ml of water and worked up accordingly. Yield: 0.6 g (61% of theory), boiling point: 65° C./0.1 mbar.
Sources & evidence
- ORD record
- ord-c591c70a87c442868b7d0095b2069e17
- Source dataset
- uspto-grants-1997_10
- Patent number
- US05679689
Reaction notes
Loading…