HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiopheneethanamine → HCID 58603419, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiopheneethanamine | HCID 116521 | — |
| Reactant | 3-{[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-ethyl-amino}-azetidine-1-carboxylic acid tert-butyl ester | HCID 86603299 | — |
| Product | HCID 58603419 | HCID 58603419 | — |
Reaction Steps
Intermediate 105 was coupled with 2-thiophen-2-yl-ethylamine following procedure F. The resulting product was deprotected following procedure G2. LC-MS showed the product had the expected M+H+ of 437. 1H NMR (Varian 300 MHz, CD3OD, shifts relative to the solvent peak at 3.3 ppm) δ 8.71 (s, 1H), 8.40 (d, 2H), 7.98 (d, 1H), 7.75 (s, 2H), 7.21 (d, 1H), 6.93 (d, 2H), 4.61 (s, 2H), 4.03 (s, 2H), 3.13 (m, 6H), 2.85 (t, 2H), 2.67 (t, 1H), 2.39 (m, 2H), 1.81 (m, 4H), 1.29 (t, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732444B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-5d58374880ca4cd58028a606be3a92f8 |
| Source note | uspto-grants-2010_06 |