HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 6-(4-Chlorophenyl)-4,5-Dihydropyridazin-3(2H)-One
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 3-(4-Chlorobenzoyl)propionic acid | HCID 77604 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-(4-Chlorophenyl)-4,5-Dihydropyridazin-3(2H)-One | HCID 120990 | 80% |
Reaction Steps
To a solution of 3-(4-chlorobenzoyl)propionic acid (20g) in absolute ethanol (200 ml) was added 5 g of hydrazine monohydrate. A thick solid was formed which dissolved after heating. The resulting solution was refluxed for 3 h, cooled and the solid formed filtered and dried to yield 16 g (80%) of 6-(4-chlorophenyl)-4,5-dihydropyridazinone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05726162 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-cd96027b0a0d43cfb4c23e75a82d466d |
| Source note | uspto-grants-1998_03 |