2-(3-Benzyloxypropyl)-3-hydroxy-gamma-butyrolactone → 2-(3-Hydroxypropyl)-3-hydroxy-gamma-butyrolactone
Reaction equation
C([O:8][CH2:9][CH2:10][CH2:11][CH:12]1[CH:17]([OH:18])[CH2:16][O:15][C:13]1=[O:14])C1C=CC=CC=1>C(O)C.C(O)(=O)C.[Pd]>[OH:8][CH2:9][CH2:10][CH2:11][CH:12]1[CH:17]([OH:18])[CH2:16][O:15][C:13]1=[O:14]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of 18.7 g of 2-(3-benzyloxypropyl)-3-hydroxy-γ-butyrolactone in 90 ml of ethanol-acetic acid (2:1) is hydrogenated over 640 mg of 10% palladium on carbon at 45 psi for 20 h. The catalyst is filtered and the filtrates are evaporated to give 2-(3-hydroxypropyl)-3-hydroxy-γ-butyrolactone as an oil.
Workup
- filtrationThe catalyst is filtered
- customthe filtrates are evaporated
Sources & evidence
- ORD record
- ord-010b69b71e544316854b40939d0eaf01
- Source dataset
- uspto-grants-1994_12
- Patent number
- US05371096
Reaction notes
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